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CDK6 anticorps (pTyr13)

CDK6 Reactivité: Humain, Souris WB, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN401597
  • Antigène Voir toutes CDK6 Anticorps
    CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
    Épitope
    • 22
    • 21
    • 14
    • 11
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr13
    Reactivité
    • 127
    • 48
    • 25
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Humain, Souris
    Hôte
    • 110
    • 17
    Lapin
    Clonalité
    • 99
    • 28
    Polyclonal
    Conjugué
    • 68
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CDK6 est non-conjugé
    Application
    • 76
    • 38
    • 29
    • 27
    • 27
    • 24
    • 23
    • 13
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This Antibody detects endogenous levels of CDK6 only when phosphorylated at Tyrosine 13.
    Purification
    Immunoaffinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogène
    The antiserum was produced against synthesized phosphopeptide derived from Human CDK6 around the phosphorylation site of Tyrosine 13 (Q-Q-Yp-E-C).
    Top Product
    Discover our top product CDK6 Anticorps primaire
  • Indications d'application
    Immunofluorescence: 1/100approx. 1/200. Immunohistochemistry on Paraffin Sections: 1/50approx. 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody (in aliquots) at-20 °C.
  • Antigène
    CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
    Autre désignation
    CDK6 (CDK6 Produits)
    Synonymes
    anticorps CDK6, anticorps PLSTIRE, anticorps 5830411I20, anticorps AI504062, anticorps Crk2, anticorps cyclin dependent kinase 6, anticorps cyclin-dependent kinase 6, anticorps CDK6, anticorps Cdk6
    Sujet
    CDK6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of Cdk6 first appears in mid-G1 phase, and is controlled by regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.Synonyms: Cell division protein kinase 6, PLSTIRE, Serine/threonine-protein kinase PLSTIRE
    ID gène
    1021
    NCBI Accession
    NP_001250
    UniProt
    Q00534
    Pathways
    Cycle Cellulaire, Mitotic G1-G1/S Phases
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