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GRIN2B anticorps (pTyr1474)

GRIN2B Reactivité: Humain, Rat, Souris IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN401599
  • Antigène Voir toutes GRIN2B Anticorps
    GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
    Épitope
    • 33
    • 30
    • 24
    • 23
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    • 20
    • 16
    • 10
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    • 7
    • 5
    • 3
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1474
    Reactivité
    • 197
    • 183
    • 154
    • 30
    • 27
    • 24
    • 10
    • 10
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 205
    • 40
    • 1
    Lapin
    Clonalité
    • 207
    • 39
    Polyclonal
    Conjugué
    • 109
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp GRIN2B est non-conjugé
    Application
    • 199
    • 68
    • 65
    • 65
    • 46
    • 43
    • 34
    • 24
    • 24
    • 18
    • 16
    • 11
    • 10
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (IF)
    Specificité
    NMDAR2B (phospho-Tyr1474) antibody detects endogenous levels of NMDAR2B only when phosphorylated at Tyr1474.
    Purification
    Affinity-chromatography
    Immunogène
    Synthesized phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1474 (H-V-YP-E-K)
    Top Product
    Discover our top product GRIN2B Anticorps primaire
  • Indications d'application
    Immunofluorescence: 1/100 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
  • Antigène
    GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
    Autre désignation
    NMDAR2B (GRIN2B Produits)
    Synonymes
    anticorps NMDAR2B, anticorps GluN2B, anticorps MRD6, anticorps NR2B, anticorps hNR3, anticorps nmdar2b, anticorps nr2b, anticorps AW490526, anticorps Nmdar2b, anticorps glutamate ionotropic receptor NMDA type subunit 2B, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 2B L homeolog, anticorps glutamate receptor, ionotropic, NMDA2B (epsilon 2), anticorps GRIN2B, anticorps Grin2b, anticorps grin2b.L
    Sujet
    NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain types of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.Synonyms: GRIN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDA Receptor 2B
    ID gène
    2904
    NCBI Accession
    NP_000825
    UniProt
    Q13224
    Pathways
    Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
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