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DARPP32 anticorps (pThr75)
PPP1R1B
Reactivité: Humain, Souris, Rat
IF
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-DARPP32 anticorps
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Antigène
Voir toutes DARPP32 (PPP1R1B) Anticorps
DARPP32 (PPP1R1B)
(Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B))
Épitope
Tous les épitopes à travers DARPP32 Anticorps.
pThr75
Reactivité
Toutes les réactivités sur DARPP32 Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur DARPP32 Anticorps
Lapin
Clonalité
Toutes les clonalités sur DARPP32 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers DARPP32 Anticorps
Cet anticorp DARPP32 est non-conjugé
Application
Tous les applications à travers DARPP32 Anticorps.
Immunofluorescence (IF)
Specificité
DARPP-32 (Phospho-Thr75) Antibody detects endogenous levels of DARPP-32 only when phosphorylated at threonine 75.
Purification
Affinity chromatography
Immunogène
Synthesized phosphopeptide derived from human DARPP-32 around the phosphorylation site of threonine 75 (A-Y-TP-P-P).
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Alternatives
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Information d'application
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Indications d'application
Immunofluorescence: 1/100 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Détails sur DARPP32
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Antigène
DARPP32 (PPP1R1B)
(Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B))
Autre désignation
DARPP32 (PPP1R1B Produits )
Synonymes
anticorps darpp32, anticorps darpp-32, anticorps Darpp-32, anticorps Darpp32, anticorps DARPP-32, anticorps DARPP32, anticorps AU040756, anticorps protein phosphatase 1 regulatory inhibitor subunit 1B, anticorps protein phosphatase 1, regulatory (inhibitor) subunit 1B, anticorps protein phosphatase 1 regulatory inhibitor subunit 1B S homeolog, anticorps ppp1r1b, anticorps PPP1R1B, anticorps Ppp1r1b, anticorps ppp1r1b.S
Sujet
DARPP32 is expressed in medium-sized spiny neurons that also express dopamine D1 receptors. The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 and phosphorylated DARPP32 is a potent protein phosphatase 1. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho DARPP32, thereby reducing the phosphatase 1 inhibitory activity of DARPP32.Synonyms: DARPP-32, Dopamine- and cAMP-regulated neuronal phosphoprotein, FLJ20940, PPP1R1B, Protein phosphatase 1 regulatory subunit 1B
ID gène
84152
NCBI Accession
NP_115568
UniProt
Q9UD71
Vus récemment
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