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MAPT anticorps (Ser356)

MAPT Reactivité: Humain, Souris, Rat IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN401616
  • Antigène Voir toutes MAPT Anticorps
    MAPT (Microtubule-Associated Protein tau (MAPT))
    Épitope
    • 11
    • 9
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ser356
    Reactivité
    • 213
    • 110
    • 100
    • 15
    • 12
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 200
    • 18
    • 6
    Lapin
    Clonalité
    • 194
    • 30
    Polyclonal
    Conjugué
    • 178
    • 17
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp MAPT est non-conjugé
    Application
    • 194
    • 119
    • 61
    • 36
    • 25
    • 21
    • 14
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Immunofluorescence (IF)
    Specificité
    Tau Antibody detects endogenous levels of total Tau protein.
    Purification
    Affinity chromatography
    Immunogène
    Synthesized non-phosphopeptide derived from human Tau around the phosphorylation site of serine 356(I-G-SP-L-D)
    Top Product
    Discover our top product MAPT Anticorps primaire
  • Indications d'application
    Immunofluorescence: 1/100 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
  • Antigène
    MAPT (Microtubule-Associated Protein tau (MAPT))
    Autre désignation
    MAPT / tau (MAPT Produits)
    Synonymes
    anticorps DDPAC, anticorps FTDP-17, anticorps MAPTL, anticorps MSTD, anticorps MTBT1, anticorps MTBT2, anticorps PPND, anticorps TAU, anticorps AI413597, anticorps AW045860, anticorps Mtapt, anticorps Tau, anticorps RNPTAU, anticorps pTau, anticorps tau, anticorps xtp, anticorps MAPT, anticorps PHF-tau, anticorps slc6a6, anticorps taut, anticorps wu:fc26e12, anticorps microtubule associated protein tau, anticorps microtubule-associated protein tau, anticorps microtubule associated protein tau S homeolog, anticorps Microtubule-associated protein tau, anticorps solute carrier family 6 (neurotransmitter transporter), member 6b, anticorps MAPT, anticorps Mapt, anticorps mapt.S, anticorps LOC5580230, anticorps CpipJ_CPIJ013260, anticorps tau, anticorps slc6a6b
    Sujet
    Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau
    ID gène
    4137
    NCBI Accession
    NP_001116538
    UniProt
    P10636
    Pathways
    Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size
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