ATF6B anticorps (Middle Region)
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- Antigène Voir toutes ATF6B Anticorps
- ATF6B (Activating Transcription Factor 6 beta (ATF6B))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Porc, Boeuf (Vache), Cheval, Chien
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ATF6B est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- FNRTESLRLA DELSGWVQRH QRGRRKIPQR AQERQKSQPR KKSPPVKAVP
- Homologie
- Cow: 86%, Dog: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 85%, Rat: 86%
- Attributs du produit
- This is a rabbit polyclonal antibody against CREBL1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human CREBL1
- Top Product
- Discover our top product ATF6B Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 703 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- ATF6B (Activating Transcription Factor 6 beta (ATF6B))
- Autre désignation
- CREBL1 (ATF6B Produits)
- Synonymes
- anticorps CREBL1, anticorps CREB-RP, anticorps G13, anticorps AA617266, anticorps ATF6beta, anticorps Creb-rp, anticorps Crebl1, anticorps activating transcription factor 6 beta, anticorps cyclic AMP-dependent transcription factor ATF-6 beta, anticorps ATF6B, anticorps LOC745411, anticorps Atf6b
- Sujet
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ATF6B(CREBL1) is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. ATF6B is normally found in the membrane of the endoplasmic reticulum, however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CREB-RP, FLJ10066, G13, CREBL1
Protein Interaction Partner: CREBZF, XBP1, ATF6B, CDK6, UBC, SUMO2, ATF6, NFYC, MBTPS1, PHOX2A, MBTPS2, NFYA, HCVgp1,
Protein Size: 703 - Poids moléculaire
- 77 kDa
- ID gène
- 1388
- NCBI Accession
- NM_004381, NP_004372
- UniProt
- Q99941
- Pathways
- Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction
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