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NCF4 anticorps (Middle Region)

NCF4 Reactivité: Humain, Souris, Rat, Lapin, Chien, Cheval, Cobaye, Boeuf (Vache) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN405780
  • Antigène Voir toutes NCF4 Anticorps
    NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
    Épitope
    • 19
    • 15
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 81
    • 25
    • 11
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Humain, Souris, Rat, Lapin, Chien, Cheval, Cobaye, Boeuf (Vache)
    Hôte
    • 76
    • 5
    • 1
    Lapin
    Clonalité
    • 78
    • 4
    Polyclonal
    Conjugué
    • 37
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp NCF4 est non-conjugé
    Application
    • 41
    • 26
    • 26
    • 20
    • 16
    • 12
    • 7
    • 4
    • 4
    • 3
    • 3
    Western Blotting (WB)
    Séquence
    TGIFPLSFVK ILKDFPEEDD PTNWLRCYYY EDTISTIKSV AWEGGACPAF
    Homologie
    Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against NCF4. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human NCF4
    Top Product
    Discover our top product NCF4 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 348 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
    Autre désignation
    NCF4 (NCF4 Produits)
    Synonymes
    anticorps p40phox, anticorps AI451400, anticorps NCF, anticorps P40PHOX, anticorps SH3PXD4, anticorps neutrophil cytosolic factor 4, anticorps ncf4, anticorps Ncf4, anticorps NCF4
    Sujet
    NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
    Alias Symbols: MGC3810, NCF, P40PHOX, SH3PXD4
    Protein Interaction Partner: NCF2, UBC, CORO1A, MSN, CYBB, NCF1, CYBA, TXN, PRKCD, XRCC6, PRKDC,
    Protein Size: 348
    Poids moléculaire
    39 kDa
    ID gène
    4689
    NCBI Accession
    NM_013416, NP_038202
    UniProt
    A8K4F9
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