SDHB anticorps (Middle Region)

N° du produit ABIN405954

Détail du produit anti-SDHB anticorps

Antigène: SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Cobaye, Cheval, Lapin, Boeuf (Vache), Chien, Chévre, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SDHB est non-conjugé

Application: Western Blotting (WB)

Séquence: YRWMIDSRDD FTEERLAKLQ DPFSLYRCHT IMNCTRTCPK GLNPGKAIAE

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against SDHB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SDHB

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 280 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SDHB (ABIN405954)

Qattan, Radulovic, Crawford, Godovac-Zimmermann: "Spatial distribution of cellular function: the partitioning of proteins between mitochondria and the nucleus in MCF7 breast cancer cells." dans: Journal of proteome research, Vol. 11, Issue 12, pp. 6080-101, (2012) (PubMed).

Détails sur SDHB

Antigène: SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))

Autre désignation: SDHB (SDHB Produits)

Synonymes: anticorps succinate dehydrogenase 2-3, anticorps CG3283, anticorps Dmel\\CG3283, anticorps Ip, anticorps SDH, anticorps SDH-IP, anticorps SDH-Ip, anticorps SDHb, anticorps sdhB, anticorps CWS2, anticorps IP, anticorps PGL4, anticorps SDH1, anticorps SDH2, anticorps SDHIP, anticorps 0710008N11Rik, anticorps fj46d06, anticorps wu:fj46d06, anticorps succinate dehydrogenase complex iron sulfur subunit B, anticorps succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, anticorps Succinate dehydrogenase, subunit B (iron-sulfur), anticorps succinate dehydrogenase complex subunit B, iron sulfur (Ip), anticorps succinate dehydrogenase complex, subunit B, iron sulfur (Ip), anticorps succinate dehydrogenase complex subunit B, iron sulfur (Ip) S homeolog, anticorps SDHB, anticorps SDH2-3, anticorps SdhB, anticorps sdhb, anticorps Sdhb, anticorps sdhb.S

Sujet: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IP, PGL4, SDH, SDH1, SDHIP, SDH2
Protein Interaction Partner: UBC, XRN1, ITGA4, TP53BP1, HNRNPUL2, PIGS, TIMM50, MRPL45, SLC25A22, MRPL40, MRPS5, IWS1, MRPS10, MRPL20, OCIAD1, TOMM7, NDUFB11, LAMTOR2, TMED2, TOMM40, RBM14, IQGAP1, UQCRFS1, SSBP1, SDHA, OXA1L, NDUFV2, NDUFS1, NDUFB9, NDUFB6, NDUFA10, NDUFA9, GSN, ATP
Protein Size: 280

Poids moléculaire: 31 kDa

ID gène: 6390

NCBI Accession: NM_003000, NP_002991

UniProt: P21912