14-3-3 sigma/SFN anticorps (Middle Region)

N° du produit ABIN406432

Détail du produit anti-14-3-3 sigma/SFN anticorps

Antigène: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Mouton, Cobaye, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 14-3-3 sigma/SFN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: FHYEIANSPE EAISLAKTTF DEAMADLHTL SEDSYKDSTL IMQLLRDNLT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 93%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against SFN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SFN

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 248 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-14-3-3 sigma/SFN (ABIN406432)

Lu, Zhu, Wen, Yang, Shaw, Lammer, Finnell: "Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida." dans: Birth defects research. Part A, Clinical and molecular teratology, Vol. 82, Issue 10, pp. 670-5, (2008) (PubMed).

Détails sur 14-3-3 sigma/SFN

Antigène: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Autre désignation: SFN (SFN Produits)

Synonymes: anticorps YWHAS, anticorps Er, anticorps Mme1, anticorps Ywhas, anticorps stratifin, anticorps SFN, anticorps Sfn

Sujet: SFN is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. SFN binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, SFN regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.
Alias Symbols: YWHAS
Protein Interaction Partner: FAM9B, RAB3IP, LONRF1, CCDC102B, ZC2HC1C, DTL, FAM53C, MKRN3, FOXO4, MAGEA1, CCNH, SIK3, ZFYVE19, YWHAZ, VCL, UBE2V1, SNRPF, UBE2R2, PAK2, G6PD, TARDBP, EGFR, BAD, MARK3, HDAC7, HDAC5, HDAC4, RAF1, CDC25C, MST1R, ABL1, HNRNPD, ATF2, TRIM32, COPS6, UBC, TP
Protein Size: 248

Poids moléculaire: 28 kDa

ID gène: 2810

NCBI Accession: NM_006142, NP_006133

UniProt: P31947

Pathways: Signalisation p53, Myometrial Relaxation and Contraction