ATP6V1C1 anticorps (N-Term)

N° du produit ABIN406715

Détail du produit anti-ATP6V1C1 anticorps

Antigène: ATP6V1C1 (ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1))

Épitope: N-Term

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATP6V1C1 est non-conjugé

Application: Western Blotting (WB)

Séquence: ldafvegvvk kvaqymadvl edskdkvqen llangvdlvt yitrfqwdma

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against ATP6V1C1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ATP6V1C1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 382 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ATP6V1C1 (ABIN406715)

Meo-Evoli, Almacellas, Massucci, Gentilella, Ambrosio, Kozma, Thomas, Tauler: "V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy." dans: Oncotarget, Vol. 6, Issue 29, pp. 28057-70, (2015) (PubMed).

Détails sur ATP6V1C1

Antigène: ATP6V1C1 (ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1))

Autre désignation: ATP6V1C1 (ATP6V1C1 Produits)

Synonymes: anticorps ATP6C, anticorps ATP6D, anticorps VATC, anticorps Vma5, anticorps 1700025B18Rik, anticorps U13839, anticorps vatC, anticorps ATPase, anticorps atp6v1c1, anticorps si:zc215i13.2, anticorps wu:fd12h05, anticorps atp6v1c1l, anticorps zgc:92684, anticorps ATPase H+ transporting V1 subunit C1, anticorps ATPase, H+ transporting, lysosomal V1 subunit C1, anticorps ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1, anticorps ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 L homeolog, anticorps ATPase, H+ transporting, lysosomal, V1 subunit C1a, anticorps ATPase, H+ transporting, lysosomal, V1 subunit C1b, anticorps ATP6V1C1, anticorps Atp6v1c1, anticorps atp6v1c1, anticorps atp6v1c1.L, anticorps atp6v1c1a, anticorps atp6v1c1b

Sujet: ATP6V1C1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ATP6C, ATP6D, FLJ20057, VATC, Vma5
Protein Interaction Partner: ATP6V1C1, IVNS1ABP, ATG7, DNM1L, TSN, STAT1, SNX2, SNX1, SHMT2, SHMT1, SARS, RDX, PAWR, NASP, IDE, GTF2A1, GSPT1, CTTN, PSMG3, ANP32E, TBC1D15, SNX6, VPS35, VPS29, LUC7L2, VTA1, ARFIP1, GSPT2, UBC, UBAC2, TXNDC17, MRPS35, CISD1, VASP, TYMS, SSR1, SRSF5, A
Protein Size: 382

Poids moléculaire: 42 kDa

ID gène: 528

NCBI Accession: NM_001695, NP_001686

UniProt: P21283

Pathways: Transition Metal Ion Homeostasis, Proton Transport