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p53 anticorps (AA 20-31)

TP53 Reactivité: Humain WB, ELISA, IP, IHC (fro), IHC (fp) Hôte: Souris Monoclonal Bp53-11 unconjugated
N° du produit ABIN4219254
  • Antigène Voir toutes p53 (TP53) Anticorps
    p53 (TP53) (Tumor Protein P53 (TP53))
    Épitope
    • 51
    • 41
    • 40
    • 39
    • 32
    • 30
    • 28
    • 25
    • 24
    • 24
    • 23
    • 20
    • 20
    • 20
    • 18
    • 18
    • 16
    • 16
    • 14
    • 13
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
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    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    AA 20-31
    Reactivité
    • 900
    • 273
    • 223
    • 113
    • 48
    • 35
    • 33
    • 19
    • 10
    • 8
    • 8
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 678
    • 238
    • 6
    • 2
    • 1
    • 1
    Souris
    Clonalité
    • 612
    • 313
    • 1
    Monoclonal
    Conjugué
    • 518
    • 49
    • 40
    • 26
    • 25
    • 25
    • 24
    • 24
    • 23
    • 22
    • 22
    • 13
    • 13
    • 13
    • 13
    • 13
    • 13
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp p53 est non-conjugé
    Application
    • 725
    • 335
    • 257
    • 217
    • 210
    • 151
    • 128
    • 124
    • 119
    • 65
    • 61
    • 35
    • 20
    • 17
    • 13
    • 12
    • 12
    • 10
    • 9
    • 8
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
    Specificité
    P53
     Réactivité croisée
    Humain
    Purification
    Protein A affinity column
    Immunogène
    Recombinant human p53 (transcription domain within the NH2 terminus)
    Clone
    Bp53-11
    Isotype
    IgG2a
    Top Product
    Discover our top product TP53 Anticorps primaire
  • Indications d'application
    IHC: 1:500, when using the APAAP method
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    reconstitue with 1 mL deionized water
    Concentration
    0.025 mg/mL
    Buffer
    PBS, pH 7.4, 0.09 % Sodium azide, 0.5 % BSA
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    2-8°C, extended storage at -20°C, avoid repeated freeze-thaw cycles
  • Zarka, Han, Edelson, Rosenblum: "Expression of cadherins, p53, and BCL2 in small cell carcinomas of the cervix: potential tumor suppressor role for N-cadherin." dans: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 13, Issue 2, pp. 240-3, (2003) (PubMed).

    Ohtaké, Cheng, Ida, Suzuki, Ohshiro, Zhang, Saku: "Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry." dans: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Vol. 31, Issue 10, pp. 590-7, (2002) (PubMed).

    Homann, Nees, Conradt, Dietz, Weidauer, Maier, Bosch: "Overexpression of p53 in tumor-distant epithelia of head and neck cancer patients is associated with an increased incidence of second primary carcinoma." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 7, Issue 2, pp. 290-6, (2001) (PubMed).

    Andl, Kahn, Pfuhl, Nicola, Erber, Conradt, Klein, Helbig, Dietz, Weidauer, Bosch: "Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control." dans: Cancer research, Vol. 58, Issue 1, pp. 5-13, (1998) (PubMed).

    Petersen, Song, Hügle-Dörr, Oldenburg, Bautz: "Mapping of linear epitopes recognized by monoclonal antibodies with gene-fragment phage display libraries." dans: Molecular & general genetics : MGG, Vol. 249, Issue 4, pp. 425-31, (1996) (PubMed).

    Stephen, Helminen, Lane: "Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions." dans: Journal of molecular biology, Vol. 248, Issue 1, pp. 58-78, (1995) (PubMed).

    Fisher, Gillett, Vojtĕsek, Barnes, Millis: "Problems with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation." dans: British journal of cancer, Vol. 69, Issue 1, pp. 26-31, (1994) (PubMed).

    Bártek, Bártková, Lukás, Stasková, Vojt?sek, Lane: "Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies." dans: The Journal of pathology, Vol. 169, Issue 1, pp. 27-34, (1993) (PubMed).

    Bártek, Bártková, Vojtĕsek, Stasková, Rejthar, Kovarík, Lane: "Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro." dans: International journal of cancer, Vol. 46, Issue 5, pp. 839-44, (1990) (PubMed).

  • Antigène
    p53 (TP53) (Tumor Protein P53 (TP53))
    Autre désignation
    P53 (TP53 Produits)
    Synonymes
    anticorps BCC7, anticorps LFS1, anticorps P53, anticorps TRP53, anticorps p53, anticorps Trp53, anticorps brp53, anticorps drp53, anticorps etID22686.5, anticorps fb40d06, anticorps wu:fb40d06, anticorps zgc:111919, anticorps Tp53, anticorps bbl, anticorps bfy, anticorps bhy, anticorps p44, anticorps tp53, anticorps Xp53, anticorps TP53, anticorps tumor protein p53, anticorps cellular tumor antigen p53, anticorps transformation related protein 53, anticorps tumor protein p53 L homeolog, anticorps TP53, anticorps CpipJ_CPIJ002758, anticorps Tp53, anticorps tp53, anticorps Trp53, anticorps tp53.L
    Sujet
    Excellent marker for wild-type and mutant forms of human p53 antigen. The antibody stains positively approx. 60 % of investigated carcinoma of lung, breast, colon, stomach, esophagus, pancreas, urinary bladder and testis, head and neck tumors, T-cell Leuk
    ID gène
    7157
    UniProt
    P04637
    Pathways
    Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg
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