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LAMP2 anticorps

LAMP2 Reactivité: Souris, Lapin IP, IF Hôte: Rat Monoclonal GL2A7 unconjugated
N° du produit ABIN452104
  • Antigène Voir toutes LAMP2 Anticorps
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    Reactivité
    • 113
    • 78
    • 36
    • 16
    • 3
    • 3
    • 2
    • 1
    Souris, Lapin
    Hôte
    • 86
    • 42
    • 34
    Rat
    Clonalité
    • 85
    • 76
    Monoclonal
    Conjugué
    • 60
    • 20
    • 20
    • 15
    • 11
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LAMP2 est non-conjugé
    Application
    • 115
    • 56
    • 53
    • 37
    • 34
    • 29
    • 28
    • 15
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    • 13
    • 12
    • 7
    • 5
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    • 1
    • 1
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    Immunoprecipitation (IP), Immunofluorescence (IF)
    Specificité
    The antibody detects CD107b. It will label the presumptive lysosomes and late endosomes in cells that have been permeabilized with saponin.
    Réactivité croisée (Details)
    Species reactivity (tested):Mouse, Rabbit
    Attributs du produit
    Synonyms: LAMP-2, LAMP-2C, LAMPB, Lysosome-associated membrane glycoprotein 2
    Purification
    Protein G chromatography
    Immunogène
    Purified preparation of mouse liver lysosomal membranes
    Clone
    GL2A7
    Isotype
    IgG1
    Top Product
    Discover our top product LAMP2 Anticorps primaire
  • Indications d'application
    Immunoprecipitation (1). Immunoflourescence: 1: 500-1: 1000 (1).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS pH 7.4, 0.09 % azide, in 50 % glycerol
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
    Shelf life: one year from despatch.
    Date de péremption
    12 months
  • Antigène
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    Autre désignation
    CD107b / LAMP2 (LAMP2 Produits)
    Synonymes
    anticorps CD107b, anticorps LAMP-2, anticorps LAMPB, anticorps LGP110, anticorps Lamp-2, anticorps Lamp-2a, anticorps Lamp-2b, anticorps Lamp-2c, anticorps Mac3, anticorps cd107b, anticorps lamp-2, anticorps lampb, anticorps LAMP2, anticorps lamp2, anticorps DKFZp459J126, anticorps LGP-B, anticorps sb:cb587, anticorps wu:fb14a06, anticorps zgc:103532, anticorps lysosomal associated membrane protein 2, anticorps lysosomal-associated membrane protein 2, anticorps lysosomal-associated membrane protein 2 S homeolog, anticorps lysosomal membrane glycoprotein 2, anticorps LAMP2, anticorps Lamp2, anticorps lamp2.S, anticorps lamp2
    Sujet
    Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37 % sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3). LAMP2 has also been detected at the plasma membrane of cells, as well as in cells that secrete lysosomal hydrolases. A study in the developmental expresses patterns of membrane LAMP2 transcripts indicate a possible involvement of this protein in cell-cell or cellextracellular matrix interaction, and appear to reflect tissue and cell type specific roles of lysosomes during morphogenesis (4). Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxylterminal tyrosine based motif (YXXI) (5). This stimulation has also been shown to have an associated release of histamine, leukotriene C 9$) and prostaglandin D 9@), which shows that LAMP1 and LAMP2 are activation markers for normal mast cells (5). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (6). LAMP2 has also been shown to be critical for autophagy, in conversion of early autophagic vacuoles to vacuoles which rapidly degrade their content (7).Synonyms: LAMP-2, LAMP-2C, LAMPB, Lysosome-associated membrane glycoprotein 2
    ID gène
    16784
    UniProt
    P17047
    Pathways
    Autophagy
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