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CACNA1H anticorps (AA 1019-1293)

CACNA1H Reactivité: Humain WB, IP, IF Hôte: Souris Monoclonal S55-10 unconjugated
N° du produit ABIN452269
  • Antigène Voir toutes CACNA1H Anticorps
    CACNA1H (Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H))
    Épitope
    • 13
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1019-1293
    Reactivité
    • 36
    • 18
    • 17
    Humain
    Hôte
    • 22
    • 15
    Souris
    Clonalité
    • 22
    • 15
    Monoclonal
    Conjugué
    • 17
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CACNA1H est non-conjugé
    Application
    • 25
    • 19
    • 19
    • 15
    • 15
    • 11
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
    Specificité
    This antibody detects Cav3.2 Ca2+ Channel at ~260 kDa. No cross-reactivity against Cav1.3.
    Réactivité croisée (Details)
    Species reactivity (tested):Human
    Attributs du produit
    Synonyms: Cav3.2, Voltage-dependent T-type calcium channel subunit alpha-1H, Voltage-gatedcalcium channel subunit alpha Cav3.2, Low-voltage-activated calcium channel alpha1 3.2subunit
    Purification
    Protein G chromatography
    Immunogène
    Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3. 2 (also known asvoltagedependent T-type calcium channel subunit alpha-1H
    Clone
    S55-10
    Isotype
    IgG1
    Top Product
    Discover our top product CACNA1H Anticorps primaire
  • Indications d'application
    Western blot: 1 - 10 μg/mL (if results are off, try using the lysate without boiling). Immunoprecipitation. Immunocytochemistry: 0.1 - 1.0 μg/mL (Perox).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol and 0.09 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
    Shelf life: one year from despatch.
    Date de péremption
    12 months
  • Antigène
    CACNA1H (Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H))
    Autre désignation
    CACNA1H (CACNA1H Produits)
    Synonymes
    anticorps CACNA1HB, anticorps Cav3.2, anticorps ECA6, anticorps EIG6, anticorps MNCb-1209, anticorps alpha13.2, anticorps calcium voltage-gated channel subunit alpha1 H, anticorps calcium channel, voltage-dependent, T type, alpha 1H subunit, anticorps CACNA1H, anticorps Cacna1h
    Sujet
    Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (3, 4). Studies also suggest that the up-regulations of Cav3.2 may participate in the progression of prostate cancer toward an androgen-independent stage (5).Synonyms: Cav3.2, Low-voltage-activated calcium channel alpha1 3.2 subunit, Voltage-dependent T-type calcium channel subunit alpha-1H, Voltage-gated calcium channel subunit alpha Cav3.2
    ID gène
    8912
    UniProt
    O95180
    Pathways
    C21-Steroid Hormone Metabolic Process
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