TSPO anticorps (C-Term)

N° du produit ABIN452349

Détail du produit anti-TSPO anticorps

Antigène: TSPO (Peripheral-Type Benzodiazepine Receptor (TSPO))

Épitope: C-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp TSPO est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Séquence: c-RDNHGWRGGR RLPE

Specificité: This antibody is expected to recognise one isoform of TSPO/PBR (NP_000705.2) only.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the C Terminus of the protein sequence according to NP_000705.2. Genename: TSPO

Information d'application

Indications d'application: Peptide ELISA: Detection Limit: 1/128000. Western blot: 0.1-0.3 μg/mL. Approx 35 kDa band observed in Human Brain lysates(calculated MW of 18.5 kDa according to NP_000705.2). Immunohistochemistry: 2-4 μg/mL. In paraffin embedded Human Colon shows strongcytoplasm staining of absorptive cells.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur TSPO

Antigène: TSPO (Peripheral-Type Benzodiazepine Receptor (TSPO))

Autre désignation: TSPO / BZRP (TSPO Produits)

Synonymes: anticorps LOC732875, anticorps LOC100136652, anticorps LOC100280949, anticorps BZRP, anticorps TSPO, anticorps Bzrp, anticorps IBP, anticorps PBR, anticorps Tspo1, anticorps MBR, anticorps PTBZR02, anticorps Ptbzr, anticorps RATPTBZR02, anticorps BPBS, anticorps DBI, anticorps PBS, anticorps PKBS, anticorps PTBR, anticorps mDRC, anticorps pk18, anticorps peripheral-type benzodiazepine receptor, anticorps Peripheral-type benzodiazepine receptor, anticorps putative peripheral-type benzodiazepine receptor, anticorps translocator protein, anticorps translocator protein homolog, anticorps hypothetical protein, anticorps LOC732875, anticorps MAV_3896, anticorps xccb100_2086, anticorps Smp_102510, anticorps Sros_1911, anticorps tspo, anticorps LOC100280949, anticorps PGTG_16395, anticorps TSPO, anticorps Tspo

Sujet: PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR.Synonyms: MBR, Mitochondrial benzodiazepine receptor, PBR, PKBS, Peripheral-type benzodiazepine receptor, Translocator protein

ID gène: 706

NCBI Accession: NP_000705

UniProt: P30536

Pathways: Cellular Response to Molecule of Bacterial Origin