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GDF15 anticorps (C-Term)

GDF15 Reactivité: Humain, Souris, Rat, Chimpanzé, Macaque WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN453962
  • Antigène Voir toutes GDF15 Anticorps
    GDF15 (Growth Differentiation Factor 15 (GDF15))
    Épitope
    • 18
    • 15
    • 11
    • 8
    • 7
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    Humain, Souris, Rat, Chimpanzé, Macaque
    Hôte
    • 86
    • 12
    • 3
    • 1
    Lapin
    Clonalité
    • 86
    • 15
    • 1
    Polyclonal
    Conjugué
    • 53
    • 15
    • 9
    • 8
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GDF15 est non-conjugé
    Application
    • 87
    • 54
    • 36
    • 16
    • 13
    • 13
    • 9
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts with the C-terminus of endogenous NAG-1 protein.
    Réactivité croisée (Details)
    Species reactivity (expected):Chimpanzee, Macaque, Mouse, Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Immunogène
    Synthetic peptide corresponding to the C-terminal sequence of NAG-1 protein. A residue of cysteine was added to facilitate coupling
    Isotype
    IgG
    Top Product
    Discover our top product GDF15 Anticorps primaire
  • Indications d'application
    ELISA: 1/300,000. Western Blot: 2,000 - 10,000.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.09 % (w/v) Sodium
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
  • Antigène
    GDF15 (Growth Differentiation Factor 15 (GDF15))
    Autre désignation
    GDF15 (GDF15 Produits)
    Synonymes
    anticorps GDF15, anticorps GDF-15, anticorps MIC-1, anticorps MIC1, anticorps NAG-1, anticorps PDF, anticorps PLAB, anticorps PTGFB, anticorps SBF, anticorps growth differentiation factor 15, anticorps GDF15, anticorps Gdf15
    Sujet
    The non-steroidal antiinflammatory drug (NSAID) activated gene (NAG-1) is a member of the transforming growth factor-beta (TGF-beta) superfamily. NAG-1 is also known as Macrophage Inhibitory Cytokine-1 (MIC-1), Growth Differentiation Factor 15 (GDF15), Placental Bone Morphogenetic Protein (PLAB), or Prostate Derived Factor (PDF). NAG-1 is expressed in human placenta, prostate and colon. It possesses antitumorigenic and proapoptotic activities. NAG-1 expression is dramatically increased in inflammation, injury and malignancy. Increase of NAG-1 expression is a feature of many cancers including breast, colon, pancreas and prostate. In a number of studies, NAG-1 expression was increased by a number of NSAIDs. This increase in expression may correlate with the chemopreventive effect NSAIDs seem to have with certain cancers. NAG-1 expression is also induced by PPAR gamma ligands and by several dietary compounds such as conjugated linoleic acids (CLAs), naturally occurring fatty acids in ruminant food products, indoles, epicatechin gallate, and genistein. The induced expression of NAG-1 results in a stimulation of apoptosis and inhibition of cell growth. Inhibition of NAG-1 induced expression by small interference RNA (siRNA) results in repression of induced apoptosis. NAG-1 expression is regulated by a numbers of transcription factors such as ERG-1 and Sp1. EGR-1 may be necessary for NSAID-induced NAG-1 expression. The study of expression of NAG-1 proteins, including variants, is important to define their potential role as serum biomarkers for cancer diagnosis, treatment monitoring, epidemiology study, and nutrition surveys.Synonyms: GDF-15, Growth/differentiation factor 15, MIC-1, MIC1, Macrophage inhibitory cytokine 1, NAG-1, NRG-1, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, PDF, PLAB, PTGFB, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor
    ID gène
    9518
    NCBI Accession
    NP_004855
    UniProt
    Q99988
    Pathways
    SARS-CoV-2 Protein Interactome
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