ELF3 anticorps (Middle Region)
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- Antigène Voir toutes ELF3 Anticorps
- ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))
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Épitope
- Middle Region
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Reactivité
- Humain, Boeuf (Vache), Chien, Lapin, Cheval, Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ELF3 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- GSCGAGAPSP GSSDVSTAGT GASRSSHSSD SGGSDVDLDP TDGKLFPSDG
- Homologie
- Cow: 86%, Dog: 79%, Horse: 92%, Human: 100%, Pig: 93%, Rabbit: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against ELF3. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human Elf3
- Top Product
- Discover our top product ELF3 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 371 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))
- Autre désignation
- Elf3 (ELF3 Produits)
- Synonymes
- anticorps ert, anticorps esx, anticorps epr-1, anticorps ese-1, anticorps ESE-1, anticorps ESX, anticorps jen, anticorps EPR-1, anticorps ERT, anticorps E74 like ETS transcription factor 3, anticorps E74-like factor 3, anticorps elf3, anticorps Elf3, anticorps ELF3
- Sujet
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ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.
Alias Symbols: EPR-1, ERT, ESE-1, ESX
Protein Interaction Partner: MED23, XRCC5, RPL6, XRCC6, EP300, CBR3, Jun, MYC, BTRC, UBC, PAK1, TAF9, SUMO2, TBP, EPS15, CREBBP, NFKB1, EGFR, ERBB2, EHF, GANAB, ISG15, TARS, P4HB, KRT82, KRT31, JAK1, EEF1D, DDX3X, CALR, ATIC,
Protein Size: 371 - Poids moléculaire
- 41 kDa
- ID gène
- 1999
- NCBI Accession
- NM_004433, NP_004424
- UniProt
- P78545
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