SLC1A2 anticorps (N-Term)

N° du produit ABIN487119

Détail du produit anti-SLC1A2 anticorps

Antigène: SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Cobaye, Cheval, Boeuf (Vache), Chien, Lapin, Poisson zèbre (Danio rerio), Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC1A2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: PGNPKLKKQL GPGKKNDEVS SLDAFLDLIR NLFPENLVQA CFQQIQTVTK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against SLC1A2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SLC1A2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 574 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SLC1A2 (ABIN487119)

Pretto, Kumar, Cao, Cunningham, Durbin-Johnson, Qi, Berman, Noctor, Hagerman, Pessah, Tassone et al.: "Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated ..." dans: Neurobiology of aging, Vol. 35, Issue 5, pp. 1189-97, (2014) (PubMed).

Détails sur SLC1A2

Antigène: SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))

Autre désignation: SLC1A2 (SLC1A2 Produits)

Synonymes: anticorps CG3159, anticorps Dmel\\CG3159, anticorps EAAT, anticorps dEAAT2, anticorps dEaat2, anticorps Eaat, anticorps GB16377, anticorps EAAT2, anticorps SLC1A2, anticorps Eaat2, anticorps Glt, anticorps Glt-1, anticorps GLT-1, anticorps 1700091C19Rik, anticorps 2900019G14Rik, anticorps AI159670, anticorps GLT1, anticorps MGLT1, anticorps eaat2, anticorps fj34b12, anticorps slc1a2, anticorps wu:fj34b12, anticorps zgc:65897, anticorps Excitatory amino acid transporter 2, anticorps excitatory amino acid transporter 2, anticorps solute carrier family 1 member 2, anticorps solute carrier family 1 (glial high affinity glutamate transporter), member 2, anticorps solute carrier family 1 (glial high affinity glutamate transporter), member 2b, anticorps Eaat2, anticorps Eaat-2, anticorps SLC1A2, anticorps VDBG_06180, anticorps EUBELI_01747, anticorps Trebr_0139, anticorps Slc1a2, anticorps slc1a2b

Sujet: SLC1A2 is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: EAAT2, GLT-1
Protein Interaction Partner: PML, GRB2, AJUBA, SLC1A2, MYCN, RELA,
Protein Size: 574

Poids moléculaire: 62 kDa

ID gène: 6506

NCBI Accession: NM_004171, NP_004162

UniProt: P43004

Pathways: Dicarboxylic Acid Transport