Doublecortin anticorps (N-Term)

N° du produit ABIN4886559

Détail du produit anti-Doublecortin anticorps

Antigène: Doublecortin (DCX)

Épitope: AA 74-100, N-Term

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Doublecortin est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Neuronal migration protein doublecortin(DCX) detection. Tested with WB in Human,Mouse,Rat.

Séquence: QSLRFHQNME LDFGHFDERD KTSRNMR

Réactivité croisée (Details): Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Neuronal migration protein doublecortin(DCX) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: doublecortin
Protein Name: Neuronal migration protein doublecortin

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Doublecortin (74-100aa QSLRFHQNMELDFGHFDERDKTSRNMR).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-Doublecortin (ABIN4886559)

Zhang, Du, Yang, Wang, Yu, Huang, Hu, Liu, Fu: "Granulocyte colony-stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice." dans: BMC neuroscience, Vol. 12, pp. 61, (2011) (PubMed).

Détails sur Doublecortin

Antigène: Doublecortin (DCX)

Autre désignation: DCX (DCX Produits)

Synonymes: anticorps DCX, anticorps DBCN, anticorps DC, anticorps LISX, anticorps SCLH, anticorps XLIS, anticorps Dbct, anticorps 18C15.5, anticorps doublecortin, anticorps DCX, anticorps Dcx

Sujet: Neuronal migration protein doublecortin, also known as doublin or lissencephalin-X, is a protein that in humans is encoded by the DCX gene. This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: DBCN | Dbct | DC | DCX | Doublecortex | Doublin | Lis X | Lis-X | Lissencephalin X | Lissencephalin-X | LISX | SCLH | XLIS | O43602

ID gène: 1641

UniProt: O43602