ATG7 anticorps (C-Term)
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- Antigène Voir toutes ATG7 Anticorps
- ATG7 (ATG7 Autophagy Related 7 (ATG7))
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Épitope
- C-Term
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ATG7 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- Specificité
- Recognizes APG7L/ATG7 (C-term).
- Réactivité croisée (Details)
- Species reactivity (tested):Human and Mouse.
- Purification
- Immunoaffinity Chromatography
- Immunogène
- APG7 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of Human APG7L/ATG7 (NP_006386).
- Isotype
- IgG
- Top Product
- Discover our top product ATG7 Anticorps primaire
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- Indications d'application
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ELISA. Western blot: APG7 antibody can be used for the detection of APG7 at 0.5-1 μg/mL. Positive Control: Caco-2 Cell Lysate. Immunocytochemistry. Positive Control: MCF7 Cell Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- ATG7 (ATG7 Autophagy Related 7 (ATG7))
- Autre désignation
- APG7L / ATG7 (ATG7 Produits)
- Sujet
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme, this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles (5). It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death (6).Synonyms: APG7-like, Autophagy-related protein 7, Ubiquitin-activating enzyme E1-like protein
- ID gène
- 10533
- NCBI Accession
- NP_006386
- UniProt
- O95352
- Pathways
- Response to Water Deprivation, Autophagy
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