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GOPC anticorps (Middle Region)

GOPC Reactivité: Humain, Souris WB, IF, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN497985
  • Antigène Voir toutes GOPC Anticorps
    GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))
    Épitope
    • 15
    • 11
    • 7
    • 7
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 82
    • 33
    • 10
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain, Souris
    Hôte
    • 81
    • 1
    Lapin
    Clonalité
    • 73
    • 9
    Polyclonal
    Conjugué
    • 29
    • 8
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GOPC est non-conjugé
    Application
    • 44
    • 30
    • 30
    • 14
    • 14
    • 11
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    Recognizes PIST (Intermediate Domain).
    Réactivité croisée (Details)
    Species reactivity (tested):Human and Mouse.
    Purification
    Immunoaffinity Chromatography
    Immunogène
    17 amino acid peptide from near the center of Human PIST (Genbank accession No. AAG00572).
    Isotype
    IgG
    Top Product
    Discover our top product GOPC Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: PIST antibody can be used for the detection ob PIST at 1-2 μg/mL. Positive Control: PC-3 Cell Lysate. Immunohistochemistry on paraffin sections. Positive Control: Rat Colon Cell Lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))
    Autre désignation
    GOPC / PIST (GOPC Produits)
    Synonymes
    anticorps DKFZp459H2130, anticorps 2210402P09Rik, anticorps AI844555, anticorps CAL, anticorps FIG, anticorps GOPC1, anticorps PIST, anticorps fe38f01, anticorps wu:fe38f01, anticorps zgc:56254, anticorps zgc:65853, anticorps dJ94G16.2, anticorps cal, anticorps gopc1, anticorps pist, anticorps golgi associated PDZ and coiled-coil motif containing, anticorps golgi-associated PDZ and coiled-coil motif containing, anticorps golgi-associated PDZ and coiled-coil motif containing S homeolog, anticorps GOPC, anticorps Gopc, anticorps gopc, anticorps gopc.S
    Sujet
    Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). PIST, a PDZ-containing protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (4-6). Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1. (6)Synonyms: CAL, CFTR-associated ligand, FIG, Fused in glioblastoma, Golgi-associated PDZ and coiled-coil motif-containing protein, PDZ protein interacting specifically with TC10
    ID gène
    57120
    NCBI Accession
    NP_001017408
    UniProt
    Q9HD26
    Pathways
    Maintenance of Protein Location, Asymmetric Protein Localization
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