GLUT4 anticorps (C-Term)

N° du produit ABIN499128

Détail du produit anti-GLUT4 anticorps

Antigène: GLUT4 (SLC2A4) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache)

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp GLUT4 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-TELEYLGPDE ND

Specificité: Recognizes SLC2A4 / GLUT4.

Réactivité croisée (Details): Species reactivity (expected):Human, Cow, Pig.
Species reactivity (tested):Mouse, Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence from the C-Terminus of the protein of Human SLC2A4 (NP_001033.1). Genename: SLC2A4

Information d'application

Indications d'application: Peptide ELISA: Limit Dilution: 1/16000. Western blot: 0.2-0.5 μg/mL. This antibody detects a band of approx. 45 kDa in Mouse and RatHeart lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur GLUT4

Antigène: GLUT4 (SLC2A4) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4))

Autre désignation: GLUT4 / SLC2A4 (SLC2A4 Produits)

Synonymes: anticorps GLUT4, anticorps Glut-4, anticorps Glut4, anticorps glut4, anticorps slc2a4, anticorps SLC2A4, anticorps solute carrier family 2 member 4, anticorps solute carrier family 2 (facilitated glucose transporter), member 4, anticorps solute carrier family 2 (facilitated glucose transporter), member 4 L homeolog, anticorps SLC2A4, anticorps Slc2a4, anticorps GLUT4, anticorps slc2a4.L

Sujet: The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.Synonyms: GLUT-4, Glucose transporter 4, Glucose transporter type 4 insulin-responsive, Solute carrier family 2 facilitated glucose transporter member 4

ID gène: 6517

NCBI Accession: NP_001033

UniProt: P14672

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Proton Transport, Brown Fat Cell Differentiation, L'effet Warburg