AMBRA1 anticorps (N-Term)

N° du produit ABIN499273

Détail du produit anti-AMBRA1 anticorps

Antigène: AMBRA1 (Autophagy/beclin-1 Regulator 1 (AMBRA1))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AMBRA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to AMBRA1.

Purification: Affinity chromatography purified via peptide column

Immunogène: Ambra1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human Ambra1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Ambra1 antibody can be used for the detection of Ambra1 at 2 - 4 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur AMBRA1

Antigène: AMBRA1 (Autophagy/beclin-1 Regulator 1 (AMBRA1))

Autre désignation: AMBRA1 (AMBRA1 Produits)

Synonymes: anticorps 2310079H06Rik, anticorps A130023A14, anticorps AA474864, anticorps AV021921, anticorps D030051N19Rik, anticorps mKIAA1736, anticorps Nyw1, anticorps DCAF3, anticorps WDR94, anticorps autophagy and beclin 1 regulator 1, anticorps autophagy/beclin-1 regulator 1a, anticorps autophagy/beclin 1 regulator 1, anticorps AMBRA1, anticorps ambra1a, anticorps Ambra1

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death . Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.Synonyms: Activating molecule in BECN1-regulated autophagy protein 1, KIAA1736

ID gène: 55626

UniProt: Q9C0C7

Pathways: Autophagy