APC2 anticorps (Center)

N° du produit ABIN499293

Détail du produit anti-APC2 anticorps

Antigène: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Épitope: Center

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APC2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogène: APC2 antibody was raised against an 18 amino acid peptide near the center of human APC2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: APC2 antibody can be used for detection of APC2 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur APC2

Antigène: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Autre désignation: APC2 (APC2 Produits)

Synonymes: anticorps APCL, anticorps AI852447, anticorps R75424, anticorps APC2, WNT signaling pathway regulator, anticorps adenomatosis polyposis coli 2, anticorps APC2, anticorps Apc2

Sujet: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.Synonyms: APC-like, APCL, Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like

ID gène: 10297

UniProt: O95996

Pathways: Signalisation WNT