ATF6 anticorps (C-Term)

N° du produit ABIN499351

Détail du produit anti-ATF6 anticorps

Antigène: ATF6 (Activating Transcription Factor 6 (ATF6))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody was raised against a 16 amino acid peptide from near the carboxy terminus of Human ATF6. ATF6 has two isoforms (ATF6? and ATF6B), only ATF6? is recognized by this antibody.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human ATF6 (C-Terminus) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: ATF6 antibody can be used for the detection of ATF6 at 0.5 - 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ATF6

Antigène: ATF6 (Activating Transcription Factor 6 (ATF6))

Autre désignation: ATF6 alpha (ATF6 Produits)

Synonymes: anticorps ATF-6-like, anticorps GB16435, anticorps ATF6, anticorps Atf6, anticorps ATF6A, anticorps 9130025P16Rik, anticorps 9630036G24, anticorps AA789574, anticorps Atf6alpha, anticorps ESTM49, anticorps activating transcription factor 6, anticorps uncharacterized LOC412432, anticorps activating transcription factor 6 S homeolog, anticorps cyclic AMP-dependent transcription factor ATF-6 alpha, anticorps ATF6, anticorps LOC412432, anticorps atf6.S, anticorps LOC100122162, anticorps Atf6

Sujet: Disruptions of protein folding and maturation in the endoplasmic reticulum (ER) result in the activation of the unfolded protein response (UPR), an integrated cellular signaling pathway that transmits information from the ER lumen to the cytoplasm and nucleus. Activating transcription factor 6 (ATF6) as well as the ER-transmembrane protein kinases IRE1p and PERK are the major transducers of the UPR . ATF6 is an ER transmembrane protein that is normally bound to the ER chaperone GRP78, but upon ER stress is released from GRP78 and proteolytically cleaved to yield a cytosolic fragment which then migrates to the nucleus, and together with the transcription factor XBP-1, activates transcription of UPR-responsive genes (2-4).Synonyms: ATF-6, Activating transcription factor 6 alpha, Cyclic AMP-dependent transcription factor ATF-6 alpha, cAMP-dependent transcription factor ATF-6 alpha

ID gène: 22926

NCBI Accession: NP_031374

UniProt: P18850

Pathways: ER-Nucleus Signaling, Unfolded Protein Response