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Caspase 12 anticorps (Intermediate Domain)

CASP12 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499549
  • Antigène Voir toutes Caspase 12 (CASP12) Anticorps
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    Épitope
    • 16
    • 15
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Intermediate Domain
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 88
    • 3
    • 1
    Lapin
    Clonalité
    • 89
    • 3
    Polyclonal
    Conjugué
    • 39
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Caspase 12 est non-conjugé
    Application
    • 78
    • 40
    • 29
    • 28
    • 26
    • 26
    • 20
    • 19
    • 10
    • 6
    • 5
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    Caspase-12 antibody was raised against a peptide corresponding to amino acids 100 to 116 of murine caspase-12.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    Mouse Caspase-12 (Intermediate Domain) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product CASP12 Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: Caspase-12 antibody can be used for detection of caspase-12 at 0.5 to 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    Autre désignation
    Caspase-12 (CASP12 Produits)
    Synonymes
    anticorps Caspase-12, anticorps CASP-12, anticorps CASP12P1, anticorps caspase 12, anticorps caspase 12 (gene/pseudogene), anticorps Casp12, anticorps CASP12
    Sujet
    Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including beta-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues (1).Synonyms: CASP-12, CASP12, Inactive caspase-12
    ID gène
    100044205
    UniProt
    O08736
    Pathways
    Apoptose, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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