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CXCR4 anticorps (Isoform A, N-Term)

CXCR4 Reactivité: Humain WB, IF, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499700
  • Antigène Voir toutes CXCR4 Anticorps
    CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
    Épitope
    • 23
    • 15
    • 15
    • 12
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Isoform A, N-Term
    Reactivité
    • 156
    • 101
    • 76
    • 22
    • 13
    • 12
    • 11
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 125
    • 29
    • 13
    • 11
    • 1
    Lapin
    Clonalité
    • 135
    • 44
    Polyclonal
    Conjugué
    • 99
    • 9
    • 8
    • 8
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CXCR4 est non-conjugé
    Application
    • 119
    • 58
    • 57
    • 36
    • 31
    • 25
    • 25
    • 24
    • 21
    • 12
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificité
    This antibody is specific for the longer isoform of CXCR4.
    Purification
    Purified
    Immunogène
    A peptide corresponding to nine amino acids near the amino terminus of Human CXCR4 isoform a.
    Isotype
    IgG
    Top Product
    Discover our top product CXCR4 Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: 5 - 1 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
    Autre désignation
    CD184 / CXCR4 (CXCR4 Produits)
    Synonymes
    anticorps CD184, anticorps D2S201E, anticorps FB22, anticorps HM89, anticorps HSY3RR, anticorps LAP3, anticorps LCR1, anticorps LESTR, anticorps NPY3R, anticorps NPYR, anticorps NPYRL, anticorps NPYY3R, anticorps WHIM, anticorps Cmkar4, anticorps PB-CKR, anticorps PBSF/SDF-1, anticorps Sdf1r, anticorps CXC-R4-B, anticorps CXCR-4-B, anticorps cd184, anticorps cxcr4, anticorps fb22, anticorps hm89, anticorps hsy3rr, anticorps lap3, anticorps lcr1, anticorps lestr, anticorps npy3r, anticorps npyr, anticorps npyrl, anticorps npyy3r, anticorps xcxcr4, anticorps CXC-R4, anticorps CXCR-4, anticorps d2s201e, anticorps whim, anticorps CXC-R4-A, anticorps CXCR-4-A, anticorps xCXCR4, anticorps CXCR4, anticorps cb403, anticorps zgc:109863, anticorps cb824, anticorps C-X-C motif chemokine receptor 4, anticorps chemokine (C-X-C motif) receptor 4, anticorps C-X-C motif chemokine receptor 4 S homeolog, anticorps C-X-C chemokine receptor type 4, anticorps C-X-C motif chemokine receptor 4 L homeolog, anticorps chemokine (C-X-C motif), receptor 4b, anticorps chemokine (C-X-C motif) receptor 4a, anticorps CXCR4, anticorps Cxcr4, anticorps cxcr4.S, anticorps cxcr4, anticorps LOC100049444, anticorps cxcr4.L, anticorps cxcr4b, anticorps cxcr4a
    Sujet
    Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites. This antibody is specific for the longer isoform of CXCR4.Synonyms: C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor, NPYRL, SDF1 receptor, Stromal cell-derived factor 1 receptor
    ID gène
    7852
    NCBI Accession
    NP_001008540
    UniProt
    P61073
    Pathways
    Regulation of Cell Size, CXCR4-mediated Signaling Events
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