DACT2 anticorps (N-Term)

N° du produit ABIN499702

Détail du produit anti-DACT2 anticorps

Antigène: DACT2 (Dapper, Antagonist of beta-Catenin 2 (DACT2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DACT2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to DACT2.

Purification: Affinity chromatography purified via peptide column

Immunogène: Dact2 antibody was raised against a 12 amino acid peptide from near the amino terminus of human DACT2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Références pour anticorps anti-DACT2 (ABIN499702)

Tan, Li, Huang, Cheng, Zhao, Chen, Chen, Tang, Zhang, Huang, Cheng: "Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway." dans: Cell death & disease, Vol. 8, Issue 8, pp. e2981, (2018) (PubMed).

Zhao, Herman, Brock, Sheng, Zhang, Liu, Guo: "Methylation of DACT2 promotes papillary thyroid cancer metastasis by activating Wnt signaling." dans: PLoS ONE, Vol. 9, Issue 11, pp. e112336, (2015) (PubMed).

Détails sur DACT2

Antigène: DACT2 (Dapper, Antagonist of beta-Catenin 2 (DACT2))

Autre désignation: DACT2 (DACT2 Produits)

Sujet: The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a b-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-b receptors. At least two isoforms of Dact2 are known to exist.Synonyms: C6orf116, DAPPER2, DPR2, PP13671, dapper homolog 2

ID gène: 168002

NCBI Accession: NP_999627

UniProt: Q5SW24