DACT3 anticorps (N-Term)

N° du produit ABIN499704

Détail du produit anti-DACT3 anticorps

Antigène: DACT3 (Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DACT3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to DACT3.

Purification: Affinity chromatography purified via peptide column

Immunogène: Dact3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Dact3.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur DACT3

Antigène: DACT3 (Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3))

Autre désignation: DACT3 (DACT3 Produits)

Synonymes: anticorps EG666671, anticorps naa-3, anticorps DAPPER3, anticorps RRR1, anticorps RGD1563892, anticorps dishevelled binding antagonist of beta catenin 3, anticorps dishevelled-binding antagonist of beta-catenin 3, anticorps DACT3, anticorps Dact3

Sujet: The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/b-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.Synonyms: DAPPER3, RRR1, antagonist of beta-catenin dapper homolog 3, arginine-rich region 1 protein, dapper homolog 3

ID gène: 147906

UniProt: Q96B18