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DARC anticorps (N-Term)

DARC Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499712
  • Antigène Voir toutes DARC Anticorps
    DARC (Duffy Blood Group, Chemokine Receptor (DARC))
    Épitope
    • 12
    • 12
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 40
    • 10
    • 6
    Humain
    Hôte
    • 31
    • 8
    • 2
    • 2
    Lapin
    Clonalité
    • 35
    • 7
    • 1
    Polyclonal
    Conjugué
    • 25
    • 4
    • 4
    • 4
    • 3
    • 3
    Cet anticorp DARC est non-conjugé
    Application
    • 29
    • 26
    • 10
    • 7
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to DARC.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    DARC antibody was raised against a 18 amino acid peptide from near the amino terminus of human DARC.
    Isotype
    IgG
    Top Product
    Discover our top product DARC Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    DARC (Duffy Blood Group, Chemokine Receptor (DARC))
    Autre désignation
    CD234 / DARC (DARC Produits)
    Synonymes
    anticorps DARC, anticorps FY, anticorps ACKR1, anticorps CCBP1, anticorps CD234, anticorps Dfy, anticorps GPD, anticorps GpFy, anticorps WBCQ1, anticorps AA162249, anticorps Ackr1, anticorps ESTM35, anticorps Duffy blood group, chemokine receptor, anticorps atypical chemokine receptor 1 (Duffy blood group), anticorps atypical chemokine receptor 1, anticorps DARC, anticorps ACKR1, anticorps Ackr1
    Sujet
    DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.Synonyms: Duffy antigen/chemokine receptor, FY, Fy glycoprotein, GPD, Glycoprotein D, GpFy, Plasmodium vivax receptor
    ID gène
    2532
    UniProt
    Q16570
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