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EBI3 anticorps (Center)

IL-27b Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499778
  • Antigène Voir toutes EBI3 (IL-27b) Anticorps
    EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))
    Épitope
    • 15
    • 11
    • 10
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    • 58
    • 15
    • 3
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 53
    • 8
    • 4
    • 1
    Lapin
    Clonalité
    • 55
    • 11
    Polyclonal
    Conjugué
    • 32
    • 8
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp EBI3 est non-conjugé
    Application
    • 43
    • 31
    • 18
    • 13
    • 13
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to EBI3.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    EBI3 antibody was raised against a 16 amino acid peptide from near the center of human EBI3.
    Isotype
    IgG
    Top Product
    Discover our top product IL-27b Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: 2 - 4 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))
    Autre désignation
    EBI3 / IL27B (IL-27b Produits)
    Synonymes
    anticorps IL-27B, anticorps IL27B, anticorps EBI3, anticorps il-27rb, anticorps si:dkey-97a13.4, anticorps EBI-3, anticorps IL-27, anticorps Epstein-Barr virus induced 3, anticorps Epstein-Barr virus induced gene 3, anticorps EBI3, anticorps ebi3, anticorps Ebi3
    Classe de substances
    Viral Protein
    Sujet
    EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35 (1-3). Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-g, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.Synonyms: EBV-induced gene 3 protein, Epstein-Barr virus-induced gene 3 protein, IL-27 subunit beta, IL-27B, Interleukin-27 subunit beta
    ID gène
    10148
    NCBI Accession
    NP_005746
    UniProt
    Q14213
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