TNFRSF12A anticorps

N° du produit ABIN499851

Détail du produit anti-TNFRSF12A anticorps

Antigène: TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNFRSF12A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to Fn14.

Purification: Affinity chromatography purified via peptide column

Immunogène: Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western BLot: 2-4 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur TNFRSF12A

Antigène: TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))

Autre désignation: CD266 / TweakR (TNFRSF12A Produits)

Synonymes: anticorps CD266, anticorps FN14, anticorps TWEAKR, anticorps AI255180, anticorps C87282, anticorps Fn14, anticorps HPIP, anticorps TWEAK-R, anticorps TweakR, anticorps TNF receptor superfamily member 12A, anticorps tumor necrosis factor receptor superfamily, member 12a, anticorps TNFRSF12A, anticorps Tnfrsf12a

Sujet: TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.Synonyms: FGF-inducible 14, FN14, Fibroblast growth factor-inducible immediate-early response protein 14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, Tweak receptor

ID gène: 51330

NCBI Accession: NP_057723

UniProt: Q9NP84

Pathways: Apoptose, Regulation of Cell Size