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GP6 anticorps (C-Term)

GP6 Reactivité: Humain, Souris, Rat WB, IHC (p), IF, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499916
  • Antigène Voir toutes GP6 Anticorps
    GP6 (Glycoprotein VI (Platelet) (GP6))
    Épitope
    • 15
    • 13
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 46
    • 1
    Lapin
    Clonalité
    • 45
    • 1
    • 1
    Polyclonal
    Conjugué
    • 12
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GP6 est non-conjugé
    Application
    • 41
    • 18
    • 13
    • 13
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to GPVI.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    GPVI antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human GPVI.
    Isotype
    IgG
    Top Product
    Discover our top product GP6 Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    GP6 (Glycoprotein VI (Platelet) (GP6))
    Autre désignation
    Platelet Glycoprotein VI (GP6 Produits)
    Synonymes
    anticorps BDPLT11, anticorps GPIV, anticorps GPVI, anticorps 9830166G18Rik, anticorps Gm469, anticorps Gpvi, anticorps GP6, anticorps glycoprotein VI platelet, anticorps glycoprotein 6 (platelet), anticorps glycoprotein VI, anticorps platelet glycoprotein VI, anticorps GP6, anticorps Gp6, anticorps LOC103346235
    Sujet
    Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcR) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.Synonyms: GP6, GPVI, Glycoprotein 6
    ID gène
    51206
    NCBI Accession
    NP_057447
    UniProt
    Q9HCN6
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