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IL-31 anticorps (Intermediate Domain)

IL31 Reactivité: Humain, Souris WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500006
  • Antigène Voir toutes IL-31 (IL31) Anticorps
    IL-31 (IL31) (Interleukin 31 (IL31))
    Épitope
    • 15
    • 13
    • 10
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Intermediate Domain
    Reactivité
    • 57
    • 9
    • 9
    Humain, Souris
    Hôte
    • 51
    • 19
    • 1
    Lapin
    Clonalité
    • 51
    • 20
    Polyclonal
    Conjugué
    • 33
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IL-31 est non-conjugé
    Application
    • 37
    • 30
    • 22
    • 14
    • 14
    • 14
    • 10
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    IL-31 antibody was raised against a 18 amino acid peptide from near the center of human IL-31.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    Human IL-31 (Intermediate Domain) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product IL31 Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: 2.5 - 5 μg/mL. Despite its predicted size, IL-31 runs at approximately 27 - 30 kDa in SDS-PAGE.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
  • Antigène
    IL-31 (IL31) (Interleukin 31 (IL31))
    Autre désignation
    Interleukin-31 / IL31 (IL31 Produits)
    Synonymes
    anticorps IL-31, anticorps 1700013B14Rik, anticorps IL31, anticorps interleukin 31, anticorps IL31, anticorps Il31
    Sujet
    Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).Synonyms: IL-31
    ID gène
    386653
    NCBI Accession
    NP_001014358
    UniProt
    Q6EBC2
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