MARCH8 anticorps (C-Term)
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- Antigène Voir toutes MARCH8 Anticorps
- MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MARCH8 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- Specificité
- This antibody detects MARCH8.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Peptide affinity chromatography
- Immunogène
- MARCH8 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human MARCH8.
- Isotype
- IgG
- Top Product
- Discover our top product MARCH8 Anticorps primaire
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- Indications d'application
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Antigène
- MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))
- Autre désignation
- MARCH8 (MARCH8 Produits)
- Synonymes
- anticorps MARCH-VIII, anticorps MIR, anticorps RNF178, anticorps c-MIR, anticorps zgc:171495, anticorps 1300017E09Rik, anticorps Mir, anticorps Mar-08, anticorps MARCH8, anticorps membrane associated ring-CH-type finger 8, anticorps membrane-associated ring finger (C3HC4) 8, anticorps membrane associated ring-CH-type finger 8 L homeolog, anticorps MARCH8, anticorps march8, anticorps March8, anticorps march8.L
- Sujet
- MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.Synonyms: Cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCH8, MARCH-VIII, Membrane-associated RING finger protein 8, RING finger protein 178, RNF178, c-MIR
- ID gène
- 220972
- NCBI Accession
- NP_659458
- UniProt
- Q5T0T0
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