MARCH8 anticorps (C-Term)

N° du produit ABIN500234

Détail du produit anti-MARCH8 anticorps

Antigène: MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MARCH8 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody detects MARCH8.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: MARCH8 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human MARCH8.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur MARCH8

Antigène: MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))

Autre désignation: MARCH8 (MARCH8 Produits)

Synonymes: anticorps MARCH-VIII, anticorps MIR, anticorps RNF178, anticorps c-MIR, anticorps zgc:171495, anticorps 1300017E09Rik, anticorps Mir, anticorps Mar-08, anticorps MARCH8, anticorps membrane associated ring-CH-type finger 8, anticorps membrane-associated ring finger (C3HC4) 8, anticorps membrane associated ring-CH-type finger 8 L homeolog, anticorps MARCH8, anticorps march8, anticorps March8, anticorps march8.L

Sujet: MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.Synonyms: Cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCH8, MARCH-VIII, Membrane-associated RING finger protein 8, RING finger protein 178, RNF178, c-MIR

ID gène: 220972

NCBI Accession: NP_659458

UniProt: Q5T0T0