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MYD88 anticorps (C-Term)
MYD88
Reactivité: Humain, Souris, Rat
WB, EIA
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-MYD88 anticorps
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Antigène
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MYD88
(Myeloid Differentiation Primary Response Gene (88) (MYD88))
Épitope
Tous les épitopes à travers MYD88 Anticorps.
AA 279-296, C-Term
Reactivité
Toutes les réactivités sur MYD88 Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur MYD88 Anticorps
Lapin
Clonalité
Toutes les clonalités sur MYD88 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers MYD88 Anticorps
Cet anticorp MYD88 est non-conjugé
Application
Tous les applications à travers MYD88 Anticorps.
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificité
This antibody detects MYD88 at C-term.
Réactivité croisée (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Peptide affinity chromatography
Immunogène
MyD88 antibody was raised against a peptide corresponding to amino acids 279 to 296 of human MyD88, which are identical to those of mouse.
Isotype
IgG
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Information d'application
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Indications d'application
ELISA. Western blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Buffer
PBS containing 0.02 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Détails sur MYD88
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Antigène
MYD88
(Myeloid Differentiation Primary Response Gene (88) (MYD88))
Autre désignation
MYD88 (MYD88 Produits )
Synonymes
anticorps MYD88D, anticorps XMyD88, anticorps myd88d, anticorps MGC84928, anticorps CG2078, anticorps DMMYD88, anticorps DmMyD88, anticorps DmMyd88, anticorps Dmel\\CG2078, anticorps EP(2)2535, anticorps Kra, anticorps LD20892, anticorps MYD88, anticorps MyD88, anticorps Myd88F, anticorps dMyD88, anticorps dMyd88, anticorps kra, anticorps myd88, anticorps zgc:103541, anticorps GB12344, anticorps NV10640, anticorps myd88-a, anticorps myd88-b, anticorps myeloid differentiation primary response 88, anticorps myeloid differentiation primary response 88 S homeolog, anticorps myeloid differentiation primary response gene 88, anticorps CG2078 gene product from transcript CG2078-RB, anticorps myeloid differentiation primary response protein MyD88-A, anticorps myeloid differentiation primary response protein MyD88, anticorps myeloid differentiation factor 88, anticorps myeloid differentiation primary response 88 L homeolog, anticorps MYD88, anticorps myd88.S, anticorps Myd88, anticorps myd88, anticorps LOC413194, anticorps LOC100118553, anticorps LOC575153, anticorps myd88.L
Sujet
The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kappaB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.Synonyms: Myeloid differentiation primary response protein MyD88
ID gène
4615
UniProt
Q99836
Pathways
Signalisation NF-kappaB , Signalisation TLR , Neurotrophin Signaling Pathway , Activation of Innate immune Response , Cellular Response to Molecule of Bacterial Origin , Positive Regulation of Immune Effector Process , Production of Molecular Mediator of Immune Response , Toll-Like Receptors Cascades
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