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DIABLO anticorps (C-Term)

DIABLO Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500784
  • Antigène Voir toutes DIABLO Anticorps
    DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
    Épitope
    • 9
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 222-237, C-Term
    Reactivité
    • 61
    • 27
    • 26
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 54
    • 7
    • 1
    Lapin
    Clonalité
    • 44
    • 18
    Polyclonal
    Conjugué
    • 37
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Cet anticorp DIABLO est non-conjugé
    Application
    • 35
    • 17
    • 14
    • 11
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects DIABLO / SMAC at C-term.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogène
    Smac antibody was raised against a peptide corresponding to amino acids 222 to 237 of murine Smac/DIABLO.
    Isotype
    IgG
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    Discover our top product DIABLO Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 0.5 to 1 μg/mL, 25 kDa band can be detected. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
    Autre désignation
    DIABLO / SMAC (DIABLO Produits)
    Synonymes
    anticorps smac, anticorps smac3, anticorps diablo-s, anticorps 0610041G12Rik, anticorps 1700006L01Rik, anticorps AU040403, anticorps Smac, anticorps DFNA64, anticorps SMAC, anticorps DBO, anticorps XSmac, anticorps diablo, IAP-binding mitochondrial protein, anticorps diablo IAP-binding mitochondrial protein, anticorps diablo, IAP-binding mitochondrial protein L homeolog, anticorps diablo, anticorps Diablo, anticorps DIABLO, anticorps diablo.L
    Sujet
    The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identified and designated Smac/DIABLO (1,2). Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/capase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases (3-6). Smac/DIABLO is expressed in a variety of human and mouse tissues (1,2).Synonyms: Diablo homolog mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase
    ID gène
    66593
    UniProt
    Q9JIQ3
    Pathways
    Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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