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RANKL anticorps (Center)

TNFSF11 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500805
  • Antigène Voir toutes RANKL (TNFSF11) Anticorps
    RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
    Épitope
    • 16
    • 15
    • 15
    • 15
    • 15
    • 15
    • 10
    • 9
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    • 170
    • 131
    • 112
    • 46
    • 2
    • 2
    Humain, Souris, Rat
    Hôte
    • 156
    • 34
    • 16
    • 7
    • 1
    Lapin
    Clonalité
    • 171
    • 41
    • 2
    Polyclonal
    Conjugué
    • 78
    • 19
    • 17
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    Cet anticorp RANKL est non-conjugé
    Application
    • 171
    • 78
    • 78
    • 65
    • 42
    • 32
    • 29
    • 20
    • 13
    • 12
    • 7
    • 7
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects CD254 / RANKL. It will recognize both the soluble form and the uncleaved transmembrane form of RANK-L.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, Mouse and Rat.
    Purification
    Immunoaffinity Chromatography
    Immunogène
    sRANK-L antibody was raised against a 14 amino acid peptide from near the center of Human sRANK-L.
    Isotype
    IgG
    Top Product
    Discover our top product TNFSF11 Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 0.25 - 0.5 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, 0.02 % Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Kirschneck, Küchler, Wolf, Spanier, Proff, Schröder: "Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain." dans: Mediators of inflammation, Vol. 2019, pp. 2514956, (2019) (PubMed).

    Ullrich, Schröder, Jantsch, Spanier, Proff, Kirschneck: "The role of mechanotransduction versus hypoxia during simulated orthodontic compressive strain-an in vitro study of human periodontal ligament fibroblasts." dans: International journal of oral science, Vol. 11, Issue 4, pp. 33, (2019) (PubMed).

  • Antigène
    RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
    Autre désignation
    CD254 / RANKL (TNFSF11 Produits)
    Synonymes
    anticorps CD254, anticorps ODF, anticorps OPGL, anticorps OPTB2, anticorps RANKL, anticorps TRANCE, anticorps hRANKL2, anticorps sOdf, anticorps TNFSF11, anticorps Ly109l, anticorps OPG, anticorps Trance, anticorps cd254, anticorps odf, anticorps opgl, anticorps optb2, anticorps rankl, anticorps sodf, anticorps tnfsf11, anticorps trance, anticorps TNF superfamily member 11, anticorps tumor necrosis factor (ligand) superfamily, member 11, anticorps TNF receptor superfamily member 11b, anticorps TNF superfamily member 11 L homeolog, anticorps TNFSF11, anticorps Tnfsf11, anticorps TNFRSF11B, anticorps tnfsf11.L
    Sujet
    The receptor activator of NF-kappaB ligand (RANK-L) is a recently discovered member of the TNF-ligand family involved in the regulation of the T cell-dependent immune response, lymph node organogenesis and bone formation. RANK-L exists as both a normal, transmembrane form and a truncated, soluble form (sRANK-L), both of which can stimulate the receptor. Activation of T cells, such as by treatment with interleukin-7, induces RANK-L production and leads to an increase of osteoclast formation and bone loss. Finally, sRANK-L can activate the antiapoptotic kinase Akt through a signaling complex involving Src kinase and TRAF6, suggesting sRANK-L may also play a role in regulating apoptosis.Synonyms: ODF, OPGL, Osteoclast differentiation factor, Osteoprotegerin ligand, RANK Ligand, RANKL, Receptor activator of nuclear factor kappa B ligand, TNF-related activation-induced cytokine, TNFSF11, TRANCE, Tumor necrosis factor ligand superfamily member 11
    ID gène
    8600
    NCBI Accession
    NP_003692
    Pathways
    Signalisation NF-kappaB
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