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TMED10 anticorps (Center)

TMED10 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500992
  • Antigène Voir toutes TMED10 Anticorps
    TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))
    Épitope
    • 15
    • 9
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    • 58
    • 44
    • 24
    • 15
    • 14
    • 13
    • 12
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 56
    • 2
    • 1
    Lapin
    Clonalité
    • 59
    Polyclonal
    Conjugué
    • 21
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TMED10 est non-conjugé
    Application
    • 52
    • 16
    • 13
    • 13
    • 13
    • 8
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects TMED10 / TMP21 at Center.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogène
    TMP21 antibody was raised against a 18 amino acid peptide from near the center of human TMP21.
    Isotype
    IgG
    Top Product
    Discover our top product TMED10 Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))
    Autre désignation
    TMED10 / TMP21 (TMED10 Produits)
    Synonymes
    anticorps tmp21, anticorps P24(DELTA), anticorps S31I125, anticorps S31III125, anticorps TMP21, anticorps Tmp-21-I, anticorps p23, anticorps 1110014C03Rik, anticorps Tmp21, anticorps p24delta1, anticorps fe06g04, anticorps wu:fb98e10, anticorps wu:fe06g04, anticorps zgc:85681, anticorps transmembrane p24 trafficking protein 10 L homeolog, anticorps transmembrane p24 trafficking protein 10, anticorps tmed10.L, anticorps TMED10, anticorps Tmed10, anticorps tmed10
    Sujet
    TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the γ-secretase but not theεsecretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the γ and ε-sites and can lead to the accumulation of the Aβ cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased γ-secretase activity but not ε-secretase activity, and increased Aβ production, demonstrating that TMP21 can modulate γsecretase activity.Synonyms: 21 kDa transmembrane-trafficking protein, S31I125, Transmembrane emp24 domain-containing protein 10, Transmembrane protein Tmp21
    ID gène
    10972
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