TREX2 anticorps (C-Term)

N° du produit ABIN501038

Détail du produit anti-TREX2 anticorps

Antigène: TREX2 (Trex2) (three Prime Repair Exonuclease 2 (Trex2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TREX2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects TREX2. The antibody will not cross-react with the related protein TREX1.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: TREX2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human TREX2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 2 - 4 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur TREX2

Antigène: TREX2 (Trex2) (three Prime Repair Exonuclease 2 (Trex2))

Autre désignation: TREX2 (Trex2 Produits)

Synonymes: anticorps RGD1562245, anticorps three prime repair exonuclease 2, anticorps TREX2, anticorps Trex2

Sujet: TREX2 is one of two major human 3\' to 5\' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.Synonyms: 3'-5' exonuclease TREX2, Three prime repair exonuclease 2

ID gène: 11219

UniProt: Q9BQ50