Tuberin anticorps (C-Term)

N° du produit ABIN501073

Détail du produit anti-Tuberin anticorps

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tuberin est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects Tuberin / TSC2 at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogène: TSC2 antibody was raised against a 15 amino acid peptide from near the carboxy-terminus of human TSC2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur Tuberin

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Autre désignation: Tuberin / TSC2 (TSC2 Produits)

Synonymes: anticorps TSC2, anticorps fc16b02, anticorps tuberin, anticorps wu:fc16b02, anticorps LAM, anticorps TSC4, anticorps Nafld, anticorps Tcs2, anticorps Rc, anticorps TSC complex subunit 2, anticorps tuberin, anticorps hypothetical protein, anticorps tuberous sclerosis 2, anticorps TSC2, anticorps LOC5569538, anticorps tsc2, anticorps PGTG_00159, anticorps Tsc2

Sujet: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). At least three isoforms of TSC2 exist.Synonyms: TSC4, Tuberous sclerosis 2 protein

ID gène: 7249

NCBI Accession: NP_000539

Pathways: Signalisation RTK, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus