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UBE2V1 anticorps (C-Term)

UBE2V1 Reactivité: Humain, Souris, Rat WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN501100
  • Antigène Voir toutes UBE2V1 Anticorps
    UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))
    Épitope
    • 16
    • 10
    • 8
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 52
    • 20
    • 19
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 49
    • 3
    Lapin
    Clonalité
    • 52
    Polyclonal
    Conjugué
    • 16
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp UBE2V1 est non-conjugé
    Application
    • 40
    • 21
    • 14
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects UBE2V1 / CROC1.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Ion exchange chromatography
    Immunogène
    UEV1A antibody was raised against a peptide corresponding to 15 amino acids near the C- terminus of human UEV1A.
    Isotype
    IgG
    Top Product
    Discover our top product UBE2V1 Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 1 to 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))
    Autre désignation
    UBE2V1 / CROC1 (UBE2V1 Produits)
    Synonymes
    anticorps CIR1, anticorps CROC-1, anticorps CROC1, anticorps UBE2V, anticorps UEV-1, anticorps UEV1, anticorps UEV1A, anticorps 0610011J09Rik, anticorps AI256840, anticorps D7Bwg1382e, anticorps CROC-1B, anticorps ubiquitin conjugating enzyme E2 V1, anticorps ubiquitin-conjugating enzyme E2 variant 1, anticorps UBE2V1, anticorps ube2v1, anticorps Ube2v1
    Sujet
    Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity (1). There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).Synonyms: CROC-1, P/OKcl.19, TRAF6-regulated IKK activator 1 beta Uev1A, UBE2V, UEV-1, UEV1, Ubiquitin-conjugating enzyme E2 variant 1
    ID gène
    387522
    NCBI Accession
    NP_954595
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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