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XAF1 anticorps (C-Term)

XAF1 Reactivité: Humain, Souris WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN501126
  • Antigène Voir toutes XAF1 Anticorps
    XAF1 (XiAP Associated Factor 1 (XAF1))
    Épitope
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 37
    • 12
    • 4
    • 2
    Humain, Souris
    Hôte
    • 34
    • 11
    Lapin
    Clonalité
    • 36
    • 9
    Polyclonal
    Conjugué
    • 21
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp XAF1 est non-conjugé
    Application
    • 25
    • 15
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects XAF-1.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse
    Purification
    Affinity chromatography
    Immunogène
    XAF-1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human XAF-1.
    Isotype
    IgG
    Top Product
    Discover our top product XAF1 Anticorps primaire
  • Indications d'application
    ELISA. Immunohistochemistry on paraffin sections. Western blot.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    XAF1 (XiAP Associated Factor 1 (XAF1))
    Autre désignation
    XAF1 (XAF1 Produits)
    Synonymes
    anticorps BIRC4BP, anticorps HSXIAPAF1, anticorps XIAPAF1, anticorps Fbxo39, anticorps XIAP associated factor 1, anticorps xaf1, anticorps XAF1, anticorps Xaf1
    Sujet
    XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus (1,2). Overexpression of XAF-1 results in the neutralization of XIAP\'s ability to inhibit cell death (1). XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines (3). In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines (2,3). Both IFN-alpha2 and IFN-beta can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs (4).Synonyms: BIRC4-binding protein, BIRC4BP, XIAP-associated factor 1, XIAPAF1
    ID gène
    54739
    NCBI Accession
    NP_059993
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