PSMC2 anticorps (N-Term)

N° du produit ABIN501257

Détail du produit anti-PSMC2 anticorps

Antigène: PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval, Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSMC2 est non-conjugé

Application: Western Blotting (WB)

Séquence: MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED

Homologie: Cow: 100%, Dog: 100%, Goat: 77%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PSMC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PSMC2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 433 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PSMC2

Antigène: PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))

Autre désignation: PSMC2 (PSMC2 Produits)

Synonymes: anticorps xMSS1, anticorps psmc2, anticorps DDBDRAFT_0168337, anticorps DDBDRAFT_0232966, anticorps DDB_0168337, anticorps DDB_0232966, anticorps MSS1, anticorps Nbla10058, anticorps S7, anticorps NCU02840.1, anticorps zgc:63995, anticorps proteasome 26S subunit, ATPase 2 L homeolog, anticorps proteasome (prosome, macropain) 26S subunit, ATPase 2, anticorps 26S protease regulatory subunit 7, anticorps proteasome 26S subunit, ATPase 2, anticorps regulatory particle, ATPase-like-1, anticorps psmc2.L, anticorps psmc2, anticorps psmC2, anticorps PSMC2, anticorps rpt-1, anticorps GL50803_21331, anticorps EHI_080890, anticorps UREG_01412, anticorps PITG_10169, anticorps Psmc2, anticorps GL50803_86683, anticorps Tsp_09237

Sujet: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, PSMC2 is a positive modulator of Tat-mediated transactivation.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC3004, MSS1, Nbla10058, S7
Protein Interaction Partner: HUWE1, UBC, PSMD5, SPRTN, SUMO2, SHFM1, PSMD14, PSMD4, RNF2, PSMC1, CLIP1, RPS21, PSMD12, PSMD11, PSMD8, PSMD3, PSMD2, PSMD1, PSMC6, PSMC3, ADRM1, TXNL1, FBXO6, PARK2, BAG3, NOS2, SKIL, RAD23A, PCDH10, UCHL5, PSMD6, PSMD13, PSMD7, PSMC4, ZCCHC8, UFC1, MRP
Protein Size: 433

Poids moléculaire: 49 kDa

ID gène: 5701

NCBI Accession: NM_002803, NP_002794

UniProt: P35998

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway