KCNA1 anticorps (Middle Region)

N° du produit ABIN501356

Détail du produit anti-KCNA1 anticorps

Antigène: KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Porc, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNA1 est non-conjugé

Application: Western Blotting (WB)

Séquence: ISIVIFCLET LPELKDDKDF TGTVHRIDNT TVIYNSNIFT DPFFIVETLC

Homologie: Dog: 100%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against KCNA1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human KCNA1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 495 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KCNA1 (ABIN501356)

Glasscock, Voigt, McCauley, Sun, Li, Chiang, Zhou, Molina, Thomas, Schmidt, Skapura, Noebels, Dobrev, Wehrens: "Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation." dans: Basic research in cardiology, Vol. 110, Issue 5, pp. 505, (2015) (PubMed).

Tan, Lennon, Klein, Boeve, Pittock: "Clinical spectrum of voltage-gated potassium channel autoimmunity." dans: Neurology, Vol. 70, Issue 20, pp. 1883-90, (2008) (PubMed).

Détails sur KCNA1

Antigène: KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

Autre désignation: KCNA1 (KCNA1 Produits)

Synonymes: anticorps AEMK, anticorps EA1, anticorps HBK1, anticorps HUK1, anticorps KV1.1, anticorps MBK1, anticorps MK1, anticorps RBK1, anticorps KCNA1, anticorps AI840627, anticorps Kca1-1, anticorps Kv1.1, anticorps Mk-1, anticorps Shak, anticorps mceph, anticorps Kcna, anticorps Kcpvd, anticorps potassium voltage-gated channel subfamily A member 1, anticorps potassium voltage-gated channel, shaker-related subfamily, member 1, anticorps fragile site, aphidicolin type, common, fra(12)(q24), anticorps KCNA1, anticorps Kcna1, anticorps FRA12E

Sujet: KCNA1 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). Sequence Note: This RefSeq record was created largely from genomic sequence because transcripts were not available for the entire length of the gene. This transcript is supported by sequences from mouse. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MGC126782, MGC138385, MK1, RBK1
Protein Interaction Partner: KCNRG, KCNE4, DLG4, DLG1, KCNA4, KCNA3, KCNA2, RTN4, CNTNAP1,
Protein Size: 495

Poids moléculaire: 56 kDa

ID gène: 3736

NCBI Accession: NM_000217, NP_000208

UniProt: Q09470