TOP2B anticorps (Middle Region)

N° du produit ABIN501630

Détail du produit anti-TOP2B anticorps

Antigène: TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cheval, Lapin, Cobaye, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOP2B est non-conjugé

Application: Western Blotting (WB)

Séquence: ENEGDYNPGR KTSKTTSKKP KKTSFDQDSD VDIFPSDFPT EPPSLPRTGR

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against TOP2B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human TOP2B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1621 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TOP2B

Antigène: TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))

Autre désignation: TOP2B (TOP2B Produits)

Synonymes: anticorps TOP2B, anticorps D230016L12Rik, anticorps Top-2, anticorps TOPIIB, anticorps top2beta, anticorps DNA topoisomerase II beta, anticorps topoisomerase (DNA) II beta, anticorps microRNA 4442, anticorps TOP2B, anticorps Top2b, anticorps MIR4442

Sujet: TOP2B is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants, however, the second variant has not yet been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TOPIIB, top2beta
Protein Interaction Partner: BAZ1B, SUMO2, SUMO3, UBC, EIF6, RPA3, RPA2, RPA1, ERG, WHSC1, NOTCH1, ESR1, NCSTN, SNRNP200, RBM14, HNRNPR, HDAC3, XPC, TOP2A, SNRPE, SMARCE1, SMARCD2, SMARCC2, SMARCC1, SMARCB1, SMARCA4, SMARCA2, SFPQ, S100A9, MSH2, IK, SEPT7, SUMO1, CUL5, NEDD8, RANBP2,
Protein Size: 1621

Poids moléculaire: 183 kDa

ID gène: 7155

NCBI Accession: NM_001068, NP_001059

UniProt: Q02880