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FGD1 anticorps (N-Term)

FGD1 Reactivité: Humain, Boeuf (Vache), Porc, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN501687
  • Antigène Voir toutes FGD1 Anticorps
    FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))
    Épitope
    • 3
    • 2
    • 1
    • 1
    N-Term
    Reactivité
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Boeuf (Vache), Porc, Rat
    Hôte
    • 8
    Lapin
    Clonalité
    • 8
    Polyclonal
    Conjugué
    • 8
    Cet anticorp FGD1 est non-conjugé
    Application
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    HGHRAPGGAG PSEPEHPATN PPGAAPPACA DSDPGASEPG LLARRGSGSA
    Homologie
    Cow: 86%, Human: 100%, Pig: 86%, Rat: 79%
    Attributs du produit
    This is a rabbit polyclonal antibody against FGD1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human FGD1
    Top Product
    Discover our top product FGD1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 961 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Zou, Greenblatt, Shim, Kant, Zhai, Lotinun, Brady, Hu, Gygi, Baron, Davis, Jones, Glimcher: "MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice." dans: The Journal of clinical investigation, Vol. 121, Issue 11, pp. 4383-92, (2011) (PubMed).

  • Antigène
    FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))
    Autre désignation
    FGD1 (FGD1 Produits)
    Synonymes
    anticorps AAS, anticorps FGDY, anticorps MRXS16, anticorps ZFYVE3, anticorps FYVE, RhoGEF and PH domain containing 1, anticorps FGD1, anticorps Fgd1, anticorps fgd1
    Sujet
    FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: AAS, FGDY, ZFYVE3, MRXS16
    Protein Interaction Partner: BTRC, UBC, ELAVL1, ELMO1, CTTN, CDC42, AOC1,
    Protein Size: 961
    Poids moléculaire
    106 kDa
    ID gène
    2245
    NCBI Accession
    NM_004463, NP_004454
    UniProt
    P98174
    Pathways
    Neurotrophin Signaling Pathway
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