SH3RF1 anticorps (Middle Region)

N° du produit ABIN502370

Détail du produit anti-SH3RF1 anticorps

Antigène: SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Lapin, Cobaye, Cheval, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH3RF1 est non-conjugé

Application: Western Blotting (WB)

Séquence: LLKLLSGAST KRKPRVSPPA SPTLEVELGS AELPLQGAVG PELPPGGGHG

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SH3RF1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SH3RF1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 888 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SH3RF1

Antigène: SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))

Autre désignation: SH3RF1 (SH3RF1 Produits)

Synonymes: anticorps SH3MD2, anticorps posh, anticorps xPOSH, anticorps rnf142, anticorps sh3md2, anticorps MGC135632, anticorps MGC189605, anticorps POSH, anticorps RNF142, anticorps 2200003J05Rik, anticorps Posh, anticorps R75531, anticorps Sh3md2, anticorps si:ch211-114c9.2, anticorps si:dkey-15j16.4, anticorps wu:fi42f11, anticorps SH3 domain containing ring finger 1, anticorps SH3 domain containing ring finger 1 S homeolog, anticorps SH3RF1, anticorps sh3rf1, anticorps sh3rf1.S, anticorps Sh3rf1

Sujet: SH3RF1 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3RF1 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
Alias Symbols: FLJ21602, KIAA1494, POSH, RNF142, SH3MD2
Protein Interaction Partner: YWHAB, UBE2N, UBE2D3, UBE2D1, AKT2, AKT1, SIAH2, SIAH1, SH3RF2, RAC1, SEMA6A, UBC, PDCD6IP, KCNJ1, MAP4K3, MAP3K9, ADAM15, PAK2, RACGAP1, MAP3K12, MAP3K10, MAP3K11,
Protein Size: 888

Poids moléculaire: 93 kDa

ID gène: 57630

NCBI Accession: NM_020870, NP_065921

UniProt: Q7Z6J0