KDELR3 anticorps (Middle Region)

N° du produit ABIN502774

Détail du produit anti-KDELR3 anticorps

Antigène: KDELR3 (kDELR3) (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 3 (kDELR3))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDELR3 est non-conjugé

Application: Western Blotting (WB)

Séquence: AYVTVYMIYG KFRKTFDSEN DTFRLEFLLV PVIGLSFLEN YSFTLLEILW

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against KDELR3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human KDELR3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 214 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KDELR3 (ABIN502774)

Collins, Wright, Edwards, Davis, Grinham, Cole, Goward, Aguado, Mallya, Mokrab, Huckle, Beare, Dunham: "A genome annotation-driven approach to cloning the human ORFeome." dans: Genome biology, Vol. 5, Issue 10, pp. R84, (2004) (PubMed).

Détails sur KDELR3

Antigène: KDELR3 (kDELR3) (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 3 (kDELR3))

Autre désignation: KDELR3 (kDELR3 Produits)

Synonymes: anticorps ERD2L3, anticorps AI173274, anticorps ERD2, anticorps kdelr, anticorps KDEL endoplasmic reticulum protein retention receptor 3, anticorps KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3, anticorps KDEL endoplasmic reticulum protein retention receptor 3 L homeolog, anticorps KDELR3, anticorps Kdelr3, anticorps kdelr3.L

Sujet: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins.Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described.
Alias Symbols: ERD2L3
Protein Interaction Partner: UBC,
Protein Size: 214

Poids moléculaire: 25 kDa

ID gène: 11015

NCBI Accession: NM_006855, NP_006846

UniProt: O43731

Pathways: ER-Nucleus Signaling, Maintenance of Protein Location