INPP5B anticorps (Middle Region)

N° du produit ABIN503565

Détail du produit anti-INPP5B anticorps

Antigène: INPP5B (Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Lapin, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INPP5B est non-conjugé

Application: Western Blotting (WB)

Séquence: IHNGQVPCHF EFINKPDEES YCKQWLNANP SRGFLLPDSD VEIDLELFVN

Homologie: Dog: 85%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 77%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against INPP5B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human INPP5B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 913 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-INPP5B (ABIN503565)

Tothova, Kollipara, Huntly, Lee, Castrillon, Cullen, McDowell, Lazo-Kallanian, Williams, Sears, Armstrong, Passegué, DePinho, Gilliland: "FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress." dans: Cell, Vol. 128, Issue 2, pp. 325-39, (2007) (PubMed).

Détails sur INPP5B

Antigène: INPP5B (Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B))

Autre désignation: INPP5B (INPP5B Produits)

Synonymes: anticorps 75kDa, anticorps AW260155, anticorps INPP5P, anticorps 5PTase, anticorps inositol polyphosphate-5-phosphatase B, anticorps type II inositol 1,4,5-trisphosphate 5-phosphatase-like, anticorps inositol polyphosphate-5-phosphatase B L homeolog, anticorps inositol polyphosphate 5-phosphatase OCRL-1, anticorps INPP5B, anticorps LOC100224437, anticorps inpp5b.L, anticorps LOC100159919, anticorps Inpp5b

Sujet: Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B is the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus.Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Alias Symbols: 5PTase, MGC65156, MGC71303
Protein Interaction Partner: UBC, APP, SMURF1,
Protein Size: 913

Poids moléculaire: 77 kDa

ID gène: 3633

NCBI Accession: NM_005540, NP_005531

UniProt: P32019