Carabin anticorps (N-Term)

N° du produit ABIN503788

Détail du produit anti-Carabin anticorps

Antigène: Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))

Épitope: N-Term

Reactivité: Humain, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Carabin est non-conjugé

Application: Western Blotting (WB)

Séquence: MAQALGEDLV QPPELQDDSS SLGSDSELSG PGPYRQADRY GFIGGSSAEP

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Pig: 93%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against TBC1D10C. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TBC1D10C

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 446 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Carabin

Antigène: Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))

Autre désignation: TBC1D10C (TBC1D10C Produits)

Synonymes: anticorps CARABIN, anticorps EPI64C, anticorps 1810062O14Rik, anticorps AI428527, anticorps RGD1311490, anticorps TBC1 domain family member 10C, anticorps TBC1 domain family, member 10c, anticorps TBC1 domain family, member 10C, anticorps TBC1D10C, anticorps Tbc1d10c

Sujet: TBC1D10C inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. TBC1D10C acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.Carabin is an endogenous inhibitor of calcineurin (see MIM 114105) that also inhibits the Ras (see MIM 190020) signaling pathway through its intrinsic Ras GTPase-activating protein activity (Pan et al., 2007 [PubMed 17230191]).[supplied by OMIM].
Alias Symbols: FLJ00332, MGC46488, EPI64C, CARABIN
Protein Interaction Partner: NOTCH2NL, KRTAP13-1, KLHL12, KRTAP5-9, HOXA1, APP, PPP3R2,
Protein Size: 446

Poids moléculaire: 50 kDa

ID gène: 374403

NCBI Accession: NM_198517, NP_940919

UniProt: Q8IV04